Computation in biological brain tissue consumes several orders of magnitude less power than silicon-based systems. Motivated by this fact, this project aims to develop the world’s first hybrid neuro-in-silico Artificial Intelligence (AI) computer, introducing a fundamentally new paradigm of AI computing. In this high-risk high-gain project, we will combine an in-silico Bayesian control agent (BCA) with neural tissue hosted by a microfluidic Brain-on-Chip (BoC) that together form a hybrid learning system capable of solving real-world AI problems.